TUMOR MICROENVIRONMENT HETEROGENEITY AN IMPORTANT MEDIATOR OF PROSTATE CANCER PROGRESSION AND THERAPEUTIC RESISTANCE

Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance

Abstract Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy Phosphatidyl Choline and drug development.In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer.We also discuss tumor Jackets heterogeneity and phenotypic switching related to ant

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Production, use, transfer of prodrug substances, and direct or indirect infringement of the patent: Focusing on the dapagliflozin formate case

This study explored whether the utilization of dapagliflozin formate, a dapagliflozin prodrug, constitutes direct (including literal infringement and infringement under the doctrine of equivalents) and indirect infringement, against a patent covering a broader concept encompassing dapagliflozin.Dapagliflozin formate differs from the patented invent

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